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Mehmed II sends his elite troops into the teeth of Emperor Constantine's defenses along the city's ancient stone walls. The defenders, led by Italian soldier-of-fortune Giovanni Giustiniani, repel every attack. Mehmed's men dig underground tunnels in an attempt to shatter city walls. The tides turn against the Ottomans when a naval blockade founders.

Dr Chris van Tulleken, Dr Hannah Fry and Michael Mosley examine the latest research and explore some of the big questions about Covid-19 and the pandemic it has created. Michael visits the UK government's high-security laboratory Porton Down, where vaccines are being tested. He also uncovers what the experience of the 2002 SARs epidemic reveals about this one. Both were caused by coronaviruses, but certain key changes to today's virus have allowed it to infect the world, where SARs was contained.

Our Sun has served Earth well for almost five billion years. It's bathed us with heat and energy. But like humans, our home star is mortal. In five billion years, it will stop nurturing its planetary offspring. The aging star will bloat out beyond the orbit of our planet incinerating all living things--including humans if we're still around.

Gravity is the most powerful and exacting force in the universe. It is pervasive and penetrating. Gravity binds us together, its reach hangs stars in the sky and its grip crushes light. Gravity holds planets together, and leashes them to their suns. Without gravity, stars, comets, moons, nebulae, and even the Earth itself would not exist. Explore how science and humanity discovered, overcame and utilized gravity. Learn what it takes to propel objects into the heavens, to ride a wave or to ski down a slope. Take a front row seat as an astronaut subjects himself to the weightless wonders of the specially modified aircraft used to train astronauts known as the "Vomit Comet."

In this programme, Mary descends into the city streets to discover the dirt, crime, sex and slum conditions in the world's first high-rise city. This Rome is not the marble Rome we know, but a vast, messy metropolis with little urban planning, where most Romans lived in high-rise apartment blocks with little space, light, or even sanitation. Forced outdoors into the city streets, she reveals where they went to hang out, get drunk, have sex and get clean. She looks at the Forum as a place of gamblers, dentists and thieves, and she explores the lustiness of Roman bar life and jokes. Finally, exploring law and order from the bottom up, Mary examines how this city really worked. She meets Ancarenus Nothus, an apartment dweller who lived in fear of the rent collector; Notorious Primus, who wrote about his three great pleasures in life - baths, wine and sex; and Unlucky Doris, a seven-year-old girl killed in one of Rome's many fires.

Sultan Mehmed II's siege of Constantinople enters its third week. Mehmed's artillery teams continue their relentless bombardment of Constantinople's walls. After his navy suffers a devastating defeat, Mehmed moves his ships overland to the Golden Horn in a daring, visionary feat. In the shadow of betrayal, Giustiniani attacks the Ottoman fleet.