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Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

A look at the solar system's largest planet, Jupiter; its formation and composition and its mini-solar system of over 60 moons – some of which may have the potential to support extra-terrestrial life.

Take an exhilarating, unprecedented exploration of the seven most amazing wonders of our solar system. Our virtual tour begins with a trip to Enceladus, one of Saturn's outer moons, where icy geysers spout from its surface. Then venture to Saturn's famous rings, which contain mountain ranges that rival the Alps. Next dive into the eye of the biggest storm in the solar system--Jupiter's Great Red Spot. Soar through the Asteroid Belt, containing millions of leftover rocks from the formation of the solar system. Trek up Mount Olympus, the largest volcano, located on Mars. Have a close encounter with the searing surface of the Sun, and finish the journey by exploring our home planet Earth.

The journeys of the Voyager probes is put in the context of the Netherlands in the seventeenth century, with a centuries-long tradition of sailing ship explorers, and its contemporary thinkers (such as Constantijn Huygens and his son Christian). Their discoveries are compared to the Voyager probes' discoveries among the Jovian and Saturn systems. In Cosmos Update, image processing reconstructs Voyager’s worlds and Voyager’s last portrait of the Solar System as it leaves is shown.

Beneath Jupiter's swirling clouds lie our solar system's deepest secrets: from its violent youth, through the birth of life to the death of the sun. Now, scientists are unlocking these secrets and discovering that every living thing exists thanks to Jupiter.

Does life exist on other planets? Astrobiology is a visionary new science that searches for life in space by combining the disciplines of astronomy, biology and geology. How did life evolve on Earth? What will life look like on other planets? These and other pertinent questions will be answered by a diverse group of scientists. Viewers will visit the Pilbara region of West Australia where the oldest evidence of life on Earth has been discovered. Travel to the moons of Jupiter and Saturn to test a theory that life could exist in the clouds of Venus. Finally, watch as experiments are done to see if life exists on exoplanets, earth-like planets beyond our solar system.