Gaby Roslin and Amir Khan present a program in which they apply the latest science to some of the worst sleepers. They include an extreme snorer, a man who suffers from night terrors, a woman who has restless leg syndrome, and a man with chronic insomnia for 20 years. The film also shows a sleep deprivation experiment to test for risky behaviour, pain resistance and emotional control. When the subjects reach the final hours of the challenge, the experiment begins to take its toll as the participants' emotions go into overdrive, with one threatening to quit altogether.
With the defeat of the Egyptian fleet at Actium, Mark Antony and Cleopatra retreat to their palace and await their fate. Believing that Cleopatra has taken her life, Mark Antony decides follow her into the afterlife. She has other plans however and is quite prepared to negotiate with Octavian if there is any possibility her life and those of her children will be spared. Cleopatra asks Vorenus to take her son Caesarian to safety and Octavian sends Pullo after them. The old friends are soon together again.
Seven years have passed since Antony's departure from Rome, and the former commander, dissipated and debauched - held in thrall by the charms and sexual prowess of his new bride, Cleopatra, withholds precious shipments of grain from Rome, where people die in the streets from hunger. Unable to incite a war with Antony and Egypt without committing political suicide, Octavian sends Atia and Octavia to Alexandria to mediate and reason with Antony; a strategy which proves predictably unsuccessful.
Octavian takes a new bride, Livia, and then introduces her to his family in a startling way... by having her witness the punishment he metes out to Atia and Octavia, for secretly defying the social constraints established through the facade of Octavia's marriage to Mark Antony. The vengeful Gaia carries out her plan to poison Eirene, which produces most dire consequences for Pullo, and no one else is the wiser. Meanwhile, Octavian, Antony, Maecenas, and their associates barely maintain their relationships of congenial contempt and hypocrisy, as everyone tries to figure out who has duped whom with the disappearance of the gold that was Herod's 'gift.'
Inconsolable at the death of Brutus at Philippi, Servilia makes her final bid to gain the ultimate vengeance against Atia. Meanwhile, Eirene and Gaia have a major falling-out, prompting Eirene to demand that Pullo properly chastise the slave. When he does, the dynamic between the two of them changes in a violent and unexpected fashion. King Herod engages Mark Antony as a reluctant ally by offering a generous gift of 20,000 pounds of gold.
Cicero is finally undone by his duplicity in the form of Titus Pullo, acting upon Octavian's request to assassinate all supporters of Brutus in Rome. Pullo and Vorenus enjoy a happy if counterfeit outing with their families in the countryside to hide their assassin mission. Vorena the Elder's dangerous dalliance with one of Mimeo's men continues, and the torrid affair between Octavia and Agrippa escalates. Atia's casual cruelty to ask for the assassination of people she doesn't like results in complete disaster for Octavia's friend Jocasta.
The film also shows a sleep deprivation experiment to test for risky behaviour, pain resistance and emotional control. When the subjects reach the final hours of the challenge, the experiment begins to take its toll as the participants' emotions go into overdrive, with one threatening to quit altogether.