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The story of the British Library's Royal Manuscripts collection reaches its end with the last great flowering of illumination, in the magnificent courts of the Tudors. Dr Janina Ramirez investigates astrological texts created for Henry VII, and unwraps his will - still in its original, extravagantly-decorated velvet and gold cover. She hears music written for Henry VIII, which went unperformed for centuries; and reads love notes between the king and Anne Boleyn, written in the margins of a prayer book. Nina also visits Bruges, the source of many of the greatest manuscripts, where this medieval art form collided with the artistic innovations of the Renaissance.

Carl Sagan opens the program with a description of the cosmos and the Spaceship of the Imagination. The ship journeys through the universe's hundred billion galaxies, the Local Group, the Andromeda Galaxy, the Milky Way, the Orion Nebula, our Solar System, and finally the planet Earth. Eratosthenes' successful calculation of the circumference of Earth leads to a description of the ancient Library of Alexandria. Finally, the Ages of Science are described, before pulling back to the full span of the Cosmic Calendar.

Sagan reflects on the future of humanity and the question of 'who speaks for Earth?' when meeting extraterrestrials. He discusses the very different meetings of the Tlingit people and explorer Jean-François de La Perouse with the destruction of the Aztecs by Spanish conquistadors, the looming threat of nuclear warfare, and the threats shown by destruction of the Library of Alexandria and the murder of Hypatia. The episode ends with an overview of the beginning of the universe, the evolution of life, and the accomplishments of humanity and makes a plea to mankind to cherish life and continue its journey in the cosmos. The Cosmos Update notes the preliminary reconnaissance of planets with spacecraft, the fall of the Berlin Wall and the end of apartheid in South Africa, and measures towards the reduction of nuclear weapons.

This is the story of a book that could have changed the history of the World. To the untrained eye, it is nothing more than a small and unassuming Byzantine prayer book. For faintly visible beneath the prayers on its pages are other, unique, writings - words that have been lost for nearly two thousand years. The text is the only record of work by one of the world's greatest minds - the ancient Greek, Archimedes - a mathematical genius centuries ahead of his time. Hidden for a millennium in a middle eastern library, it has been written over, broken up, painted on, cut up and re-glued. But in the nick of time scientists have saved the precious, fragile document, and for the first time it is revealing just how revolutionary Archimedes' ideas were. If it had been available to scholars during the Renaissance, we might have reached the Moon over a hundred years ago.