Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

The word Anunnaki means "princely seed" or "princely blood". The idea is that the Anunnaki were direct creations of Anu, who was regarded as the father and king of the gods. Ancient Aliens: "In the ancient texts of Sumeria we have descriptions of these being descending from the sky called the Anunnaki. The term Anunnaki means 'those who from the heavens came."

The final part reveals how our knowledge of cells has brought us to the brink of one of the most important moments in history. Scientists are close to repeating what has happened only once in four billion years - the creation of a new life form.