Find out what is being done to prevent the end of the world from threats from outer space such as comets and asteroids. Also discussed are apocalyptic scenarios.

Some 65 million years ago, the dinosaurs were wiped out when their gene machines failed to cope with the cataclysmic changes that followed a comet's collision with Earth. But with extinction came new life, and surviving mammals evolved to seize the territory left vacant by the vanquished. The concluding episode explores the factors that make winners and losers in the game of life, and poses the question: Who will triumph in the long run?

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Sagan discusses comets and asteroids as planetary impactors, giving recent examples of the Tunguska event and a lunar impact described by Canterbury monks in 1178. It moves to a description of the environment of Venus, from the previous fantastic theories of people such as Immanuel Velikovsky to the information gained by the Venera landers and its implications for Earth's greenhouse effect. The Cosmos Update highlights the connection to global warming.