Seven years have passed since Antony's departure from Rome, and the former commander, dissipated and debauched - held in thrall by the charms and sexual prowess of his new bride, Cleopatra, withholds precious shipments of grain from Rome, where people die in the streets from hunger.
Unable to incite a war with Antony and Egypt without committing political suicide, Octavian sends Atia and Octavia to Alexandria to mediate and reason with Antony; a strategy which proves predictably unsuccessful.

With the defeat of the Egyptian fleet at Actium, Mark Antony and Cleopatra retreat to their palace and await their fate. Believing that Cleopatra has taken her life, Mark Antony decides follow her into the afterlife. She has other plans however and is quite prepared to negotiate with Octavian if there is any possibility her life and those of her children will be spared. Cleopatra asks Vorenus to take her son Caesarian to safety and Octavian sends Pullo after them. The old friends are soon together again.

Someday, I will die. But should I? If I was offered a longer life, I would take that in a second. But how long is too long? Is death something I should deny forever, or is death and the role it plays in the universe something I am better off accepting?

The second episode takes a look at how humans have always been voyagers and explorers, leaving the comfort of native shores to explore. Neil DeGrasse Tyson will show us a long-term vision of humanity's future worlds.

In the second part and conclusion, a spotlight on the mass marketing of the synthetic opioid fentanyl examines the connections between drug manufacturers and government policy. Video of sales retreats and promotional material reveals a deep cynicism among company employees and a disregard for the widespread, nefarious corporate practices.

The second episode of the series looks at dreams and tries to explain what happens in the brain and body after we go to sleep. It looks at the significance of dreams and what dreams can teach us about ourselves. It talks to neuroscientists who discuss slow-wave sleep and REM (rapid eye movement) sleep during which dreams occur. It looks at the history of dream interpretation and its validity.