In the final part, Professor Al-Khalili uncovers tales of success and heartache in the story of chemists' battle to control and combine the elements, and build our modern world. He reveals the dramatic breakthroughs which harnessed their might to release almost unimaginable power, and he journeys to the centre of modern day alchemy, where scientists are attempting to command the extreme forces of nature and create brand new elements.

The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.

This episode explores how scientists delved ever deeper into the world of the cell, seeking to reveal the magic ingredient that can spark a bundle of chemicals into life. Their discoveries have brought us to the brink of being able to create life for ourselves.

In this episode, Michael demonstrates how our society is built on our search to find the answer to what makes up everything in the material world. This is a story that moves from the secret labs of the alchemists and their search for gold by the stone of the philosophers to the creation of the world's first synthetic dye - Purple - and onto the invention of the transistor. This quest may seem abstract and highly theoretical. Yet it has delivered the greatest impact on humanity. By trying to answer this question, scientists have created theories from elements to atoms, and the strange concepts of quantum physics that underpin our modern, technological world.

Al-Khalili travels to northern Syria to discover how, a thousand years ago, the great astronomer and mathematician Al-Biruni estimated the size of the earth to within a few hundred miles of the correct figure. He discovers how medieval Islamic scholars helped turn the magical and occult practice of alchemy into modern chemistry. In Cairo, he tells the story of the extraordinary physicist Ibn al-Haytham, who helped establish the modern science of optics and proved one of the most fundamental principles in physics - that light travels in straight lines. Prof Al-Khalili argues that these scholars are among the first people to insist that all scientific theories are backed up by careful experimental observation, bringing a rigour to science that didn't really exist before.

Without the chemistry of photosynthesis, ozone, and a molecule called Rubisco, none of us would be here. So how did we get so lucky? To find out, host David Pogue investigates the surprising molecules that allowed life on Earth to begin, and ultimately thrive. Along the way, he finds out what we’re all made of—literally.