Carl Sagan opens the program with a description of the cosmos and the Spaceship of the Imagination. The ship journeys through the universe's hundred billion galaxies, the Local Group, the Andromeda Galaxy, the Milky Way, the Orion Nebula, our Solar System, and finally the planet Earth. Eratosthenes' successful calculation of the circumference of Earth leads to a description of the ancient Library of Alexandria. Finally, the Ages of Science are described, before pulling back to the full span of the Cosmic Calendar.

The word Anunnaki means "princely seed" or "princely blood". The idea is that the Anunnaki were direct creations of Anu, who was regarded as the father and king of the gods. Ancient Aliens: "In the ancient texts of Sumeria we have descriptions of these being descending from the sky called the Anunnaki. The term Anunnaki means 'those who from the heavens came."

Shocking new evidence has convinced some of the world's greatest physicists that the universe is a hologram. Using cutting-edge technology, they investigate the secrets of black holes and space-time to build the case for this game-changing discovery.
The holographic principle is a supposed property of quantum gravity that states that the description of a volume of space can be thought of as encoded on a lower-dimensional boundary to the region like a gravitational horizon. First proposed by Gerard 't Hooft, it was given a precise string-theory interpretation by Leonard Susskind.
The holographic principle was inspired by black hole thermodynamics, which conjectures that the maximal entropy in any region scales with the radius squared, and not cubed as might be expected. In the case of a black hole, the insight was that the informational content of all the objects that have fallen into the hole might be entirely contained in surface fluctuations of the event horizon.

Sagan discusses comets and asteroids as planetary impactors, giving recent examples of the Tunguska event and a lunar impact described by Canterbury monks in 1178. It moves to a description of the environment of Venus, from the previous fantastic theories of people such as Immanuel Velikovsky to the information gained by the Venera landers and its implications for Earth's greenhouse effect. The Cosmos Update highlights the connection to global warming.

Rembrandt's success in his early years was as a portrait painter to the rich denizens of Amsterdam at a time when the city was being transformed from a small nondescript port into the economic capital of the world. His historical and religious paintings also gave him wide acclaim. Despite being known as a portrait painter Rembrandt used his talent to push the boundaries of painting. This direction made him unpopular in the later years of his career as he shifted from being the talk of the town to becoming adrift in the Amsterdam art scene and criticised by his peers.

Director James Cameron returns to the site of the 1912 wreck of the RMS Titanic. With a team of history and marine experts he embarks on an unscripted adventure back to the final grave of 1,517 people. Using two small, purpose-built remotely operated vehicles, we can see inside the Titanic and with the help of CGI, view the ship's original appearance superimposed on the deep-dive images. Throughout the movie, there are re-enactments of events that are discussed that use CGI recreations of the interior of the Titanic. The documentary was named one of the Best 3D movies ever by Rolling Stone.