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The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

We will nvestigate the first skeleton that really looks like us –Turkana Boy– an astonishingly complete specimen of Homo erectus found by the famous Leakey team in Kenya. These early humans are thought to have developed key innovations that helped them thrive, including hunting large prey, the use of fire, and extensive social bonds. The program examines an intriguing theory that long-distance running –our ability to jog– was crucial for the survival of these early hominids. Not only did running help them escape from vicious predators roaming the grasslands, but it also gave them a unique hunting strategy: chasing down prey animals such as deer and antelope to the point of exhaustion. Birth of Humanity also probes how, why, and when humans' uniquely long period of childhood and parenting began.

This episode is centered around how science, in particular the work of Clair Patterson (voiced in animated sequences by Richard Gere[33]) in the middle of the 20th century, has been able to determine the age of the Earth. Tyson first describes how the Earth was formed from the coalescence of matter some millions of years after the formation of the Sun, and while scientists can examine the formations in rock stratum to date some geological events, these can only trace back millions of years. Instead, scientists have used the debris from meteor impacts, such as the Meteor Crater in Arizona, knowing that the material from such meteors coming from the asteroid belt would have been made at the same time as the Earth. Patterson also examined the levels of lead in the common environment and in deeper parts of the oceans and Antarctic ice, showing that lead had only been brought to the surface in recent times. He would discover that the higher levels of lead were from the use of tetraethyllead in leaded gasoline resulting in government-mandated restrictions on the use of lead.

This is the story of two tiny animals coming of age. In the wild woods of North America, a young chipmunk is gathering a vital store of nuts ahead of his first winter - in his way are ruthless rivals and giant predators. In the steaming rainforest, a young tree-shrew is forced deep into the jungle to find food. She must draw on all her intelligence and agility if she is to escape the ultimate jungle predator - a reticulated python!

Series concludes with the focus shifting to the United States in the post-war years of the 1950s and beyond. Beginning with arguably the most notorious work of 20th century classical music, John Cage's 'silent' composition 4'33", it looks at how a series of maverick Americans re-invented the sound of classical music into a more simple form, bringing back harmonies and rhythms that made it increasingly popular with audiences across the world. It also examines how this music found its way into a spiritual realm, with the strain of pared-down religious composition that came to be known as 'holy minimalism'. From the Maverick concert hall in Woodstock, New York to an Orthodox cathedral in Estonia to a car park in Peckham, south London, the story is told by a stellar line-up of contributors including Philip Glass, Steve Reich, John Adams, Arvo Pärt and John Tavener.

About 340 million years ago a brand new family of animals was evolving in the primeval swamps. They were to go one step further than the amphibians who had emerged onto dry and before them. For they would eventually completely cut their ties with water. They were the ancestors of todays lizards. They evolved scaly impermeable skins and moved up into the forests. They diversified into a multitude of different shapes and sizes. They developed signalling systems to communicate with one another. And they squabbled as animals do. For food they hunted insects that were already well established on the land in great numbers. And here without returning to water they produced their families. They powered their bodies not only with food but with the heat that they drew directly from the sun.
As they diversified so they spread into the harshest of the lands habitats. The baking waterless deserts which eventually they would come to dominate. Discover jacky lizards that wave, wrestling beaded lizards and the the world's smallest chameleon, which is no bigger than his thumbnail, and the biggest lizard in Australia.