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Michael crosses Iran towards the Caspian Sea. He meets nomads who tell of Alexander's tryst with an Amazon queen, and the living descendants of Alexander's Persian enemies, who have their own tales of `Alexander the Accursed'.

This episodes the nature of the cosmos on the micro and atomic scales, using the Ship of the Imagination to explore these realms. Tyson describes some of the micro-organism that live within a dew drop, demonstrating parameciums and tardigrades. He proceeds to discuss how plants use photosynthesis via their chloroplasts to convert sunlight into chemical reactions that convert carbon dioxide and water into oxygen and energy-rich sugars. Tyson then discusses the nature of molecules and atoms and how they relate to the evolution of species. He uses the example set forth by Charles Darwin postulating the existence of the long-tongued Morgan's sphinx moth based on the nature of the comet orchid with pollen far within the flower. He further demonstrates that scents from flowers are used to trigger olfactory centers in the brain, stimulating the mind to threats as to aid in the survival of the species. Tyson narrates how Greek philosophers Thales and Democritus postulated that all matter was made up of combinations of atoms in a large number of configurations, and describes how carbon forms the basic building block for life on earth due to its unique chemical nature. Tyson explains on the basic atomic structure of protons, neutrons, and electrons, and the nature of nuclear fusion that occurs in most stars. He then discusses the existence of neutrinos that are created by these nuclear processes in stars, and that detecting such sub-atomic particles which normally pass through matter require subterranean facilities like the Super-Kamiokande that were used to detect neutrinos from the supernova SN 1987A in the Large Magellanic Cloud before light from the explosion were observed due to their ability to pass through matter of the dying sun. Tyson compares how neutrinos were postulated by Wolfgang Pauli to account for the conservation of energy from nuclear reactions in the same manner as Darwin's postulate on the long-tongued moth. Tyson concludes by noting that there are neutrinos from the Big Bang still existing in the universe but due to the nature of light, there is a "wall of infinity" that cannot be observed beyond.

Even after thousands of years of ice crushing the northern hemisphere and temperatures of 20 degrees lower than those of today, many of the great giants of the ice age still walked the earth. It was only when the world had warmed up again that mammoths, woolly rhinos, sabre-toothed cats, giant ground sloths and glyptodonts finally became extinct. Professor Alice Roberts sets off on her last voyage back to the Ice Age to discover why.

Our icy adventure begins with host Dr. Iain Stewart in the Alps, where he goes down an ice crevasse to show viewers how snowfall develops into expansive masses. Then, we see how ice can shape the earth's topography giving rise to features like Yosemite National Park and Manhattan Island, in NY. Finally, journey to Greenland and see how ice sheets and glaciers are melting at a phenomenal rate that is likely to accelerate over the coming years, changing the world as we know it.

This episode explores how scientists delved ever deeper into the world of the cell, seeking to reveal the magic ingredient that can spark a bundle of chemicals into life. Their discoveries have brought us to the brink of being able to create life for ourselves.

During 1964-1969 both sides now plan to put a man on the Moon - while the Soviets struggle, the Americans pull ahead in the space race with Project Gemini, but then suffer a disaster with the Apollo 1 fire. The Soviet space programme suffers its own blows: Sergei Korolev dies when his heart fails during an operation, Soyuz 1 crashes and kills cosmonaut Vladimir Komarov, and their planned moon rocket, the N-1 rocket, fails to successfully launch. In America, von Braun has difficulties with the Saturn V, but they are overcome, and the rocket successfully launches the first manned lunar mission, Apollo 8, and the first manned lunar landing, Apollo 11.