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The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.

No planet beats Saturn for jaw-dropping beauty. Saturn is the most photogenic planet in all the solar system. Some of the pictures are to die for. But the postcards only tell part of the story. It really is rolling and seething inside. For ringside action, soar above the planet with its six-sided storms. Even more mystery surrounds the impressive Fountains of Enceladus where the secrets of life might spring from the moons salty geysers. And the samples are coming out in space, there's a big sign there: Free Samples: Take One.

xamines the fate of the Neanderthals, our European cousins who died out as modern humans spread from Africa into Europe during the Ice Age. Did modern humans interbreed with Neanderthals or exterminate them? The program explores crucial evidence from the recent decoding of the Neanderthal genome. How did modern humans take over the world? New evidence suggests that they left Africa and colonized the rest of the globe far earlier, and for different reasons, than previously thought. As for Homo sapiens, we have planet Earth to ourselves today, but that's a very recent and unusual situation. For millions of years, many kinds of hominids co-existed. At one time Homo sapiens shared the planet with Neanderthals, Homo erectus, and the mysterious "Hobbits"–three-foot-high humans who thrived on the Indonesian island of Flores until as recently as 12,000 years ago. "Last Human Standing" examines why "we" survived while those other ancestral cousins died out. And it explores the provocative question: In what ways are we still evolving today?

The idea of intelligence is explored in the concepts of computers (using bits as their basic units of information), whales (in their songs and their disruptions by human activities), DNA, the human brain (the evolution of the brain stem, frontal lobes, neurons, cerebral hemispheres, and corpus callosum under the Triune Brain Model), and man-made structures for collective intelligence (cities, libraries, books, computers, and satellites). The episode ends with speculation on alien intelligence and the information conveyed on the Voyager Golden Record.

World War II is a watershed event for Latino Americans with hundreds of thousands of men and women serving in the armed forces, most fighting side by side with Anglos. In the Pacific, East L.A.'s Guy Gabaldon becomes a Marine Corp legend when he singlehandedly captures more enemy soldiers than anyone in US military history. But on the home front, discrimination is not dead: in 1943, Anglo servicemen battle hip young "Zoot suitors" in racially charged riots in southern California

This episodes the nature of the cosmos on the micro and atomic scales, using the Ship of the Imagination to explore these realms. Tyson describes some of the micro-organism that live within a dew drop, demonstrating parameciums and tardigrades. He proceeds to discuss how plants use photosynthesis via their chloroplasts to convert sunlight into chemical reactions that convert carbon dioxide and water into oxygen and energy-rich sugars. Tyson then discusses the nature of molecules and atoms and how they relate to the evolution of species. He uses the example set forth by Charles Darwin postulating the existence of the long-tongued Morgan's sphinx moth based on the nature of the comet orchid with pollen far within the flower. He further demonstrates that scents from flowers are used to trigger olfactory centers in the brain, stimulating the mind to threats as to aid in the survival of the species. Tyson narrates how Greek philosophers Thales and Democritus postulated that all matter was made up of combinations of atoms in a large number of configurations, and describes how carbon forms the basic building block for life on earth due to its unique chemical nature. Tyson explains on the basic atomic structure of protons, neutrons, and electrons, and the nature of nuclear fusion that occurs in most stars. He then discusses the existence of neutrinos that are created by these nuclear processes in stars, and that detecting such sub-atomic particles which normally pass through matter require subterranean facilities like the Super-Kamiokande that were used to detect neutrinos from the supernova SN 1987A in the Large Magellanic Cloud before light from the explosion were observed due to their ability to pass through matter of the dying sun. Tyson compares how neutrinos were postulated by Wolfgang Pauli to account for the conservation of energy from nuclear reactions in the same manner as Darwin's postulate on the long-tongued moth. Tyson concludes by noting that there are neutrinos from the Big Bang still existing in the universe but due to the nature of light, there is a "wall of infinity" that cannot be observed beyond.