Located in an almost inaccessible chamber deep in a South African cave, the site required recruiting a special team of experts slender enough to wriggle down a vertical, pitch-dark, seven-inch-wide passage. Most fossil discoveries of human relatives consist of just a handful of bones. But down in this hidden chamber, the team uncovered an unprecedented trove—so far, over 1,500 bones—with the potential to rewrite the story of our origins". They may help fill in a crucial gap in the fossil record and tell us how Homo, the first member of the human family, emerged from ape-like ancestors like the famous Lucy. But how did hundreds of bones end up in the remote chamber? The experts are considering every mind-boggling possibility. Join us on the treacherous descent into this cave of spectacular and enigmatic finds, and discover their startling implications for the saga of what made us human.

Hundreds of years ago in faraway Iceland the Vikings began to write down dozens of stories called sagas - sweeping narratives based on real people and real events. But as Oxford University's Janina Ramirez discovers, these sagas are not just great works of art, they are also priceless historical documents which bring to life the Viking world. Dr Ramirez travels across glaciers and through the lava fields of Iceland to the far north west of the country to find out about one of the most compelling of these stories - the Laxdaela Saga.

Carl Sagan opens the program with a description of the cosmos and the Spaceship of the Imagination. The ship journeys through the universe's hundred billion galaxies, the Local Group, the Andromeda Galaxy, the Milky Way, the Orion Nebula, our Solar System, and finally the planet Earth. Eratosthenes' successful calculation of the circumference of Earth leads to a description of the ancient Library of Alexandria. Finally, the Ages of Science are described, before pulling back to the full span of the Cosmic Calendar.

Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Ideas about time and space are explored in the changes that constellations undergo over time, the redshift and blue shift measured in interstellar objects, time dilation in Albert Einstein's theory of relativity, the designs of both Leonardo da Vinci and spacecraft that could travel near light speed, time travel and its hypothetical effects on human history, the origins of the Solar System, the history of life, and the immensity of space. In Cosmos Update, the idea of faster-than-light travel by wormholes (researched by Kip Thorne and shown in Sagan’s novel Contact) is discussed.