An informative and ambitious journey exploring how the evolution of scientific understanding is intimately interwoven with society's historical path. The Story Of Science tells the forces that came together to create scientific knowledge; the practical business of making instruments and machines; the great forces of history – revolutions, voyages of discovery and artistic movements – and the dogged determination of scientists and experimenters. This is the story of how scientific ideas shaped the modern world and how science made history. Michael Mosley begins the first episode with the story of one of the great upheavals in human history - how we came to understand that our planet was not at the centre of everything in the cosmos, but just one of billions of bodies in a vast and expanding universe. He reveals the critical role of medieval astrologers in changing our view of the heavens, and the surprising connections to the upheavals of the Renaissance, the growth of coffee shops and Californian oil and railway barons. Michael shows how important the practical skills of craftsmen have been to this story and finds out how Galileo made his telescope to peer at the heavens and by doing so helped change our view of the universe forever.

Our wheat has changed dramatically, it doesn't even resemble what it used to look like. Not only are we seeing more wheat and gluten sensitivity, there is also a strong connection between gluten and autoimmune diseases. Tens of thousands of people are suffering with ill health and don't realise it's a result of the food choices they are making. Some assume it is part of their genetic make-up or the body changing as they get older.
People need to become educated, knowledgeable and aware. They need to start making changes to improve the health of their children and future generations.

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

Africa's wildest river is home to the most spectacular wildlife. Hippos fight for territory while herds of elephant, water buffalo and zebra depend on it for life. In the wet season the rains burst the riverbanks and everyone, including people, must move whilst fish swim through the villages. In the dry season the creatures fight over the few pools of water while predators prowl. At its heart it plunges over Victoria Falls and into wild ravines before draining into the Indian Ocean, where storm clouds cycle the water back into the heart of Africa.

Zeitgeist Addendum attempts to locate the root causes of this pervasive social corruption, while offering a solution. This solution is not based on politics, morality, laws, or any other 'establishment' notions of human affairs, but rather on a modern, non-superstitious based understanding of what we are and how we align with nature, to which we are a part. The work advocates a new social system which is updated to present day knowledge, highly influenced by the life long work of Jacque Fresco and The Venus Project.