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Two thousand years ago one of history's most notorious individuals was born. Professor Mary Beard embarks on an investigative journey to explore the life and times of Gaius Julius Caesar Augustus Germanicus - better known to us as Caligula. Caligula has now become known as Rome's most capricious tyrant, and the stories told about him are some of the most extraordinary told about any Roman emperor. He was said to have made his horse a consul, proclaimed himself a living God, and indulged in scandalous orgies - even with his own three sisters - and that's before you mention building vast bridges across land and sea, prostituting senators' wives and killing half the Roman elite seemingly on a whim. All that in just four short years in power before a violent and speedy assassination in a back alley of his own palace at just 28-years-old." But how much of his story is true? Travelling across the Roman world - from Germany and Capri in the bay of Naples to the astonishing luxury of his life in imperial Rome - Mary attempts to peel away the myths. Some stories are difficult to get to the bottom of as they were written by hacks long after his death, but there is plenty of surviving evidence where the 'real' Caligula can be glimpsed. Such as in the extraordinary luxury of his private yachts outside Rome; in the designs he chose for his coins when he became Emperor; in an eye-witness account of Caligula's withering humour written in 41AD; the trial documents covering the mysterious death of his father when he was just seven-years-old; and even in a record of his imperial slaves - from the palace spy to his personal trainer. Piecing together the evidence, Mary puts Caligula back into the context of his times to reveal an astonishing story of murder, intrigue and dynastic family power. Above all, she explains why Caligula has ended up with such a seemingly unredeemable reputation. In the process, she reveals a more intriguing portrait of not just the monster, but the man.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Sagan reflects on the future of humanity and the question of 'who speaks for Earth?' when meeting extraterrestrials. He discusses the very different meetings of the Tlingit people and explorer Jean-François de La Perouse with the destruction of the Aztecs by Spanish conquistadors, the looming threat of nuclear warfare, and the threats shown by destruction of the Library of Alexandria and the murder of Hypatia. The episode ends with an overview of the beginning of the universe, the evolution of life, and the accomplishments of humanity and makes a plea to mankind to cherish life and continue its journey in the cosmos. The Cosmos Update notes the preliminary reconnaissance of planets with spacecraft, the fall of the Berlin Wall and the end of apartheid in South Africa, and measures towards the reduction of nuclear weapons.

A look at the solar system's largest planet, Jupiter; its formation and composition and its mini-solar system of over 60 moons – some of which may have the potential to support extra-terrestrial life.

This episode discusses the human exploration of Antarctica, in particular the mission led by Captain Robert Falcon Scott, whose team died on the way back from the South Pole. It shows the scientific work in the modern human bases in Antarctica, especially Mawson Base and its observation of Adelie Penguins (partially through tracking devices). The second half of the episode describes how the series was made. Most crucial was of course the camera work. To get access to the wildlife of the sea, for example, boats, divers, suspended capsules and remotely controlled cameras mounted on inflatables were used. Particularly dangerous to divers were Leopard Seals and other predators. The film concludes that although working in Antarctica is now much easier than during the early days of exploration, human footsteps on the continent are still exceedingly rare in part because of international treaties prohibiting industrial exploitation.

Join investigators as they untangle the cause of Alzheimer’s and race to develop a cure. Alzheimer’s disease strikes at the core of what makes us human: our capacity to think, to love, and to remember. The disease ravages the minds of over 40 million victims worldwide, and it is one of the greatest medical mysteries of our time. Join investigators as they gather clues and attempt to reconstruct the molecular chain of events that ultimately leads to dementia". Follow key researchers in the field who have helped to develop the leading theories of the disease. Along the way, meet individuals from all walks of life who will reveal what it’s like to struggle with Alzheimer’s. Among them, members of a unique Colombian family who have learned that their genetic predisposition all but guarantees early onset Alzheimer’s. Yet there may be hope. Join these courageous patients participating in clinical trials, and then go behind the scenes of the major drug trials to see how researchers target and test therapies that may slow and even prevent Alzheimer’s