This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

We used to think that Earth was at the centre of the universe, but now we know we're not even at the centre of our own galaxy. Countless wonders exist between where earth is situated and the massive black hole at the galactic centre of our galaxy. Within the Milky Way can be found the debris of old, dying stars fuelling the birth of new stars and at the galactic centre hypervelocity stars get catapulted clear beyond the Milky Way's outer rim at unimaginable speeds. Come along for a guided tour of 100,000 light-year-wide family of stars and stellar phenomena we call The Milky Way.

There's something very odd going on in space - something that shouldn't be possible. It is as though vast swathes of the universe are being hoovered up by a vast and unseen celestial vacuum cleaner. Sasha Kaslinsky, the scientist who discovered the phenomenon, is understandably nervous: 'It left us quite unsettled and jittery' he says, 'because this is not something we planned to find'. The accidental discovery of what is ominously being called 'dark flow' not only has implications for the destinies of large numbers of galaxies - it also means that large numbers of scientists might have to find a new way of understanding the universe. Dark flow is the latest in a long line of phenomena that have threatened to rewrite the textbooks. Does it herald a new era of understanding, or does it simply mean that everything we know about the universe is wrong?

What built the Milky Way? New research might now have the answer, revealing an unlikely hero. At the heart of our galaxy sits a super massive black hole, one of the most destructive objects in the Universe. Could it be our creator?

Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy

We can't compare anything on earth to the biggest things known in space. The Cosmic Web may connect objects in the universe with threads of Dark Matter. The Lyman-alpha blob is a bubble like structure containing countless galaxies--perhaps the biggest object in the entire universe. Regions of radio-emitting gas called "radio lobes" could be even bigger. Then there are super galaxy clusters which are hundreds of galaxies merged together due to cosmic collisions. Discover which is the largest planet, star, star cluster, constellation, black hole, volcano, galaxy, explosions, moon, storm, impact crater and "void" in space.