Medicine

Professor Marcus du Sautoy goes in search of answers to one of science's greatest mysteries: how do we know who we are? While the thoughts that make us feel as though we know ourselves are easy to experience, they are notoriously difficult to explain. He has his mind scrambled by a cutting-edge experiment in anaesthesia. After, Marcus is given an out-of-body experience in a bid to locate his true self.

The world is affected by an obesity epidemic, but why is it that not everyone is succumbing? Medical science has been obsessed with this subject and is coming up with some unexpected answers. As it turns out, it is not all about exercise and diet. At the centre of this programme is a controversial overeating experiment that aims to identify exactly what it is about some people that makes it hard for them to bulk up.

Horizon uncovers the secret world of our dreams. In a series of cutting-edge experiments and personal stories, we go in search of the science behind this most enduring mystery and ask: where do dreams come from? Do they have meaning? And ultimately, why do we dream? What the film reveals is that much of what we thought we knew no longer stands true. Dreams are not simply wild imaginings but play a significant part in all our lives as they have an impact on our memories, the ability to learn, and our mental health. Most surprisingly, we find nightmares, too, are beneficial and may even explain the survival of our species.

Cannabis is the world's favourite drug, but also one of the least understood. Can cannabis cause schizophrenia? Is it addictive? Can it lead you on to harder drugs? Or is it simply a herb, an undervalued medicine? Addiction specialist Dr John Marsden discovers that modern science is finally beginning to find answers to these questions. John traces the cannabis plants' birthplace in Kazakhstan; finds the origins of our sensitivity to cannabis in the simple sea squirt; and finds out just what it does to our brains. He meets people who have been changed by this drug in drastically different ways - from those whose lives have been shattered to those who lives have been revived.

The drug policies have remained unchanged over the last 40 years so should they be reformed in the light of new research? Recent research has analysed the link between the harmful effects of drugs relative to their current classification by law with some startling conclusions. Perhaps most startling of all is that alcohol, solvents and tobacco (all unclassified drugs) are rated more dangerous than ecstasy, 4-MTA and LSD (all class A drugs).

We are in the grip of an allergy epidemic. 50 years ago one in 30 were affected, but in Britain today it is closer to one in three. Why this should be is one of modern medicine's greatest puzzles. In search of answers, Horizon travels round the globe, from the remotest inhabited island to the polluted centres of California and the UK. We meet sufferers and the scientists who have dedicated their lives trying to answer the mystery of why we are becoming allergic to our world.