Every day our planet faces cataclysmic events that threaten our very existence. Whether from natural or man-made forces, rising from the earth or menacing from space, the world seems beset by more catastrophes than ever. Some believe the signs of the coming Apocalypse are all around us–as outlined in the bible’s most compelling book of prophecies: Revelation". And even the non-religious can’t ignore what appears to be a growing rate of globe-threatening disasters. Are we approaching a biblical “End of Times”? And if so–how will it happen? Will it come from an act of God? Or a colossal misstep of man? Get an uncomfortably close front row seat to some of the most likely apocalyptic scenarios our world faces today–and the history, both scientific and biblical, behind them.

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

Is God worshipped in other worlds, across the cosmos? How might alien deities differ from our own? The answer may lie buried on Earth. Animal behaviorists are testing elephants and finding them capable of having spiritual thoughts. Artificial intelligence researchers are building enlightened robots that contemplate the divine. Meanwhile, cosmologists are looking for universal equations that could replace God. Have advanced aliens discovered everything there is to know about the universe? Or are they looking to a higher power for answers?

Humanity’s potential seems limitless. But could we become as powerful as God? Scientific breakthroughs grant our species seemingly divine abilities. Biologists tinkering with DNA are figuring out ways to grow new life forms, while neuroscientists try to create artificial consciousness. Statisticians around the world are using big data to predict the future and computer scientists have discovered a "God algorithm" that could solve any global problem in an instant. But to truly become God, we not only have to be all knowing, but all being. Quantum physicists are figuring out how to teleport matter at the speed of light!

Researchers discuss the possibility that the creation of the Large Hadron Collider was foretold in ancient sources that were inspired by aliens

Researchers discuss mythic ancient treasure and curses including King Solomon's Ring, lost Aztec treasure, and the Omphalos.