Carl Sagan opens the program with a description of the cosmos and the Spaceship of the Imagination. The ship journeys through the universe's hundred billion galaxies, the Local Group, the Andromeda Galaxy, the Milky Way, the Orion Nebula, our Solar System, and finally the planet Earth. Eratosthenes' successful calculation of the circumference of Earth leads to a description of the ancient Library of Alexandria. Finally, the Ages of Science are described, before pulling back to the full span of the Cosmic Calendar.

In the Land of the Cave Bear, Alice ventures to the parts of the northern hemisphere, hit hardest by the cold - Europe and Siberia. High in the mountains of Transylvania, a cave sealed for thousands of years reveals grisly evidence for a fight to the death between two staving giants, a cave bear and a cave lion. Yet Alice discovers that for woolly rhinos and woolly mammoths, the Ice Age created a bounty. The Mammoth Steppe, a vast tract of land which went half way round the world, provided food all year round, for those that liked the cold. It was these mammoths that Europe's most dangerous predators hunted for their survival.

Long ago, two species of human beings coexisted on Earth until competition drove one of them to extinction. This program, set in the southwest of France 35,000 years ago, reconstructs the life in the Neanderthal world at the time Cro-Magnons first entered the scene. All aspects of Neanderthal clan life are examined, including tool- and weapon-making, hunting and gathering, health and healing, childbirth, rituals, and making fire. Footage of skeletal remains and the scholarly research of eminent paleontologist Chris Stringer and Oxford University's Paul Pettitt support the documentary.

Long ago, two species of human beings coexisted on Earth until competition drove one of them to extinction. This program, set in the southwest of France 35,000 years ago, reconstructs the life in the Neanderthal world at the time Cro-Magnons first entered the scene. All aspects of Neanderthal clan life are examined, including tool- and weapon-making, hunting and gathering, health and healing, childbirth, rituals, and making fire. Footage of skeletal remains and the scholarly research of eminent paleontologist Chris Stringer and Oxford University's Paul Pettitt support the documentary.

Has the age of antibiotics come to an end? From a young girl thrust onto life support in Arizona to an uncontrollable outbreak at one of the nation’s most prestigious hospitals, The film investigates the alarming rise of a deadly type of bacteria that our modern antibiotics can’t stop.

Moving on to Ethiopia 3.2 million years ago, we witness the beginnings of mankind via a group of australopithecus - a type of ape which, like us, walks upright on two legs. But unlike us, these early members of the human family weren't predators, they were prey. Things get worse for the group as they are hunted by a sabre-tooth cat called dinofelis and fall victim to other dangers such as malaria, rival australopithecus and a rampaging 14-tonne deinotherium.