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This scientific detective tale tells the story of a remarkable group of pioneers who wanted to reach the ultimate extreme: absolute zero, a place so cold that the physical world as we know it doesn't exist, electricity flows without resistance, fluids defy gravity and the speed of light can be reduced to 38 miles per hour. Absolute zero became the Holy Grail of temperature physicists and is considered the gateway to many new technologies, such as nano-construction, neurological networks and quantum computing. The possibilities, it seems, are limitless. The first episode Chronicles the major discoveries leading towards the mastery of cold, beginning with King James I's court magician, Cornelius Drebbel, who managed to air condition the largest interior space in the British Isles in 1620. Other stories will include the first "natural philosopher," Robert Boyle, a founder of the Royal Society in Great Britain; the Grand Duke Ferdinand II de Medici's involvement in the creation of the first thermometer; the establishment of the laws of thermodynamics by three young scientists, Sadi Carnot, James Joule and William Thomson; and Michael Faraday's critical achievement in liquefying several other gases which set the stage for the commercial application of cold to refrigeration and air conditioning.

Professor of physics Jim Al-Khalili investigates the most accurate and yet perplexing scientific theory ever - quantum physics, the perplexing theory of sub-atomic particles. Turning his attention to the world of nature, can quantum mechanics explain the greatest mysteries in biology? The European robin navigates using one of the most bizarre effects in physics - quantum entanglement, a process which seems to defy common sense. Jim finds that even the most personal of human experiences - our sense of smell - is touched by ethereal quantum vibrations. According to new experiments it seems that our quantum noses are listening to smells. Jim discovers that the most famous law of quantum physics - the uncertainty principle - is obeyed by plants and trees as they capture sunlight during the vital process of photosynthesis. Jim wonders if the strange laws of the sub-atomic world, which allow objects to tunnel through impassable barriers in defiance of common sense, could effect the mechanism by which living species evolve?

Professor Brian Cox seeks to understand the nature of time and its role in creating both the universe and ourselves. From an extraordinary calendar built into the landscape of Peru to the beaches of Costa Rica, Brian explores the cycles of time which define our experience of life on Earth. But even the most epic cycles of life can't begin to compare to the vast expanse of cosmic time. Ultimately, Brian discovers that time is not characterised by repetition but by irreversible change. The vast universe is subject to these same laws of change. As we look out to the cosmos, we can see the story of its evolution unfold, from the death of the first stars to the birth of the youngest. This journey from birth to death will ultimately lead to the destruction not just of our planet, but also the entire universe, and with it the end of time itself. Yet without this inevitable destruction, the universe would be without what is perhaps the greatest wonder of all; the brief moment in time in which life can exist.

Dr Michael Mosley traces the sinister ways the experimental psychology has used to try to control our minds. He finds that the pursuit of mind control has led to some truly horrific experiments and left many casualties in its wake. Extraordinary archive captures what happened - scientists systematically change the behaviour of children; law abiding citizens give fatal electric shocks; a gay man has electrodes implanted in his head in an attempt to turn his sexuality. Michael takes a hallucinogenic drug as part of a controlled experiment to try to understand how its mind-bending properties can change the brain. This is a scientific journey goes to the very heart of what we hold most dear - our free will, and our ability to control our own destiny.

David Attenborough asks three key questions: how and why did Darwin come up with his theory of evolution? Why do we think he was right? And why is it more important now than ever before? David starts his journey in Darwin's home at Down House in Kent, where Darwin worried and puzzled over the origins of life. David goes back to his roots in Leicestershire, where he hunted for fossils as a child, and where another schoolboy unearthed a significant find in the 1950s. And he revisits Cambridge University, where both he and Darwin studied, and where many years later the DNA double helix was discovered, providing the foundations for genetics. At the end of his journey in the Natural History Museum in London, David concludes that Darwin's great insight revolutionised the way in which we see the world. We now understand why there are so many different species, and why they are distributed in the way they are. But above all, Darwin has shown us that we are not set apart from the natural world, and do not have dominion over it. We are subject to its laws and processes, as are all other animals on earth to which, indeed, we are related.

Dr Thomas Dixon delves into the BBC's archive to explore the troubled relationship between religion and science. From the creationists of America to the physicists of the Large Hadron Collider, he traces the expansion of scientific knowledge and asks whether there is still room for God in the modern world. He looks at what happens when new scientific discoveries start to explain events that were once seen as the workings of God, and explains how some of our most famous scientists have seen God in the grandest laws of the universe. Finally, he finds intriguing evidence from brain science which hints that belief in God is here to stay.